Understanding how nerve cells in the gut develop and function
Mechanisms of Enteric Neuron Diversification
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10672040
This study is looking at how a protein called Sox10 helps develop important nerve cells in the gut, which are key for healthy digestion, and it hopes to find out how problems with this protein might cause issues like chronic constipation, so that people with digestive disorders can get better treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10672040 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control the development of enteric neurons, which are crucial for proper gastrointestinal motility and overall digestive health. By studying the role of a specific protein called Sox10, the research aims to uncover how defects in this protein can lead to conditions like chronic constipation and other bowel disorders. The approach involves analyzing genetic models to observe how these neurons differentiate and function in the gut. Patients with gastrointestinal disorders may benefit from insights gained through this research, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals experiencing chronic constipation or other functional bowel disorders.
Not a fit: Patients with gastrointestinal disorders unrelated to enteric neuron function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from gastrointestinal motility disorders.
How similar studies have performed: Other research has shown success in understanding enteric neuron development, but this specific approach focusing on Sox10 is relatively novel.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOUTHARD-SMITH, E MICHELLE — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: SOUTHARD-SMITH, E MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.