Understanding how nerve cells grow and connect in the brain
Official title: Mechanisms of Dcc Receptor Signaling in Neuronal Morphogenesis
Funded at University of Pennsylvania · NIH-11023632 · Data updated 2026-11-12
This study is looking at how nerve cells connect with each other and how a special receptor helps guide their growth, with the hope of finding new ways to help nerves heal and improve conditions that affect development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 3, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $576,841 |
| NIH project number | 1R01NS140161-01 |
| Project ID | NIH-11023632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological developmental disorders or those recovering from nerve injuries.
✕Less likely to help
Patients with purely psychiatric conditions unrelated to neuronal growth or injury may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which neurons form functional circuits in the nervous system, focusing on how axons navigate to their targets. It explores the role of the Dcc receptor in guiding axon growth and how these signals influence the development of neuronal connections. By studying the interactions between axons and their environment, the research aims to uncover potential therapeutic strategies for nerve regeneration and address developmental disorders. The approach includes examining both the cytoskeletal changes and gene transcription regulation involved in axon guidance.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to nerve damage and developmental disorders.
How similar studies have gone: Previous research has shown success in understanding axon guidance mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Bashaw, Greg J. — University of Pennsylvania
- Study coordinator: Bashaw, Greg J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.