Understanding how nerve cells communicate through membrane fusion
Official title: Fusion pore structure and dynamics
Funded at University of Wisconsin-Madison · NIH-10864477 · Data updated 2026-11-12
This study is looking at how tiny bubbles in brain cells, called synaptic vesicles, join with the cell's outer layer to help send messages between neurons, which could lead to better treatments for communication problems in the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2032 |
| Funding year | 2025 |
| Award (this year) | $660,632 |
| NIH project number | 1R35NS136306-01 |
| Project ID | NIH-10864477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological disorders that affect communication, such as autism spectrum disorder or other synaptic dysfunctions.
✕Less likely to help
Patients with non-neurological conditions or those not experiencing communication impairments may not receive direct benefits from this research.
What this research studies
This research investigates the fundamental process of membrane fusion in eukaryotic cells, specifically focusing on how synaptic vesicles merge with the presynaptic plasma membrane in neurons. By examining the dynamics of fusion pores, which are crucial for neurotransmitter release, the study aims to uncover the molecular mechanisms that facilitate this essential communication process. Utilizing advanced techniques like cryo-electron microscopy and electrophysiological measurements, the research seeks to provide insights into the biophysical principles governing these interactions. Patients may benefit from a deeper understanding of neuronal function and potential treatments for communication disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neurological conditions related to communication impairments.
How similar studies have gone: Previous research has shown success in understanding membrane fusion dynamics, but this specific approach utilizing the ND-BLM system is innovative and may provide new insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Chapman, Edwin R — University of Wisconsin-Madison
- Study coordinator: Chapman, Edwin R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.