Understanding how nerve cells communicate in health and disease.
Mechanisms of Synaptic Transmission in Healthy and Disease States
This study is looking at how nerve cells talk to each other and how problems in this communication might be linked to conditions like Fragile X syndrome and autism, with the hope of finding new ways to help those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11083017 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of synaptic transmission, focusing on how nerve cells communicate with each other. By using advanced imaging technology, the researchers aim to visualize the movement and recycling of synaptic vesicles in real-time within living tissues. They are particularly interested in how disruptions in these processes contribute to conditions like Fragile X syndrome and autism. This work could lead to a better understanding of the underlying causes of these disorders and inform potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or Fragile X syndrome.
Not a fit: Patients with unrelated neurological conditions or those without a diagnosis of autism or Fragile X syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for autism and related disorders.
How similar studies have performed: Other research has shown promising results in understanding synaptic mechanisms, but this approach using nanoscale imaging is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Klyachko, Vitaly a — Washington University
- Study coordinator: Klyachko, Vitaly a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.