Understanding how nerve cells can regenerate after injury during development
Official title: Molecular regulation over the decline in long-distance corticospinal axon regenerative ability during development
Funded at Winifred Masterson Burke Med Res Inst · NIH-11005036 · Data updated 2026-11-12
This study is looking at how nerve cells in the spinal cord can heal and grow back after being injured, especially how this ability changes as we grow up, with the hope of finding better ways to help people recover from paralysis caused by strokes or other conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winifred Masterson Burke Med Res Inst NIH-funded |
| Lab location | 1 site (White Plains, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $536,329 |
| NIH project number | 5R01NS131420-02 |
| Project ID | NIH-11005036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals under 21 years old who have experienced paralysis due to conditions such as stroke, spinal cord injury, or amyotrophic lateral sclerosis.
✕Less likely to help
Patients who are over 21 years old or those with irreversible nerve damage may not benefit from this research.
What this research studies
This research investigates the ability of corticospinal neurons to regenerate their axons after injury, focusing on how this ability changes from childhood to adulthood. By using a novel microsurgical technique, the researchers aim to assess the conditions that support long-distance axon regeneration without disrupting the spinal environment. The study seeks to identify the critical developmental stages when the regenerative capacity declines, which could lead to new strategies for enhancing recovery from paralysis caused by conditions like stroke or amyotrophic lateral sclerosis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from paralysis by enhancing nerve regeneration.
How similar studies have gone: While previous studies have shown some success in understanding nerve regeneration, this specific approach is novel and has not been extensively tested.
Where this research is happening
-
Winifred Masterson Burke Med Res Inst
White Plains, United States Active
Researchers
- Principal investigator: Sahni, Vibhu Vinodchandra — Winifred Masterson Burke Med Res Inst
- Study coordinator: Sahni, Vibhu Vinodchandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.