Understanding how nerve cells can regenerate after injury
Multicellular Mechanisms Driving Axon Regeneration
This study is exploring how some nerve cells in the brain and spinal cord can heal themselves after an injury, which could help improve movement and feeling for people with spinal cord or optic nerve damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11083058 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow certain nerve cells to regenerate their axons after injury, focusing on the central nervous system (CNS). It aims to uncover how these cells can activate a regenerative program, which is crucial for restoring mobility and sensation after spinal cord injuries or optic nerve damage. The approach involves studying the epigenomic changes that occur in response to axon injury, which may reveal new targets for therapies. By analyzing the interactions between different cell types and their environments, the research seeks to identify ways to enhance axon repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries or optic nerve damage.
Not a fit: Patients with injuries to peripheral nerves or those with conditions unrelated to axon regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore movement and sensation in patients with CNS injuries.
How similar studies have performed: Previous research has shown promise in understanding axon regeneration in peripheral nerves, but this approach focusing on the CNS is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cavalli, Valeria — Washington University
- Study coordinator: Cavalli, Valeria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.