Understanding how nerve cells affect nasal inflammation caused by allergens
Official title: Neuronal regulation of sinonasal Type 2 inflammation
Funded at Tulane University of Louisiana · NIH-11231567 · Data updated 2026-11-12
This study is looking at how certain nerve cells in the nose react to allergens during allergic fungal rhinosinusitis (AFRS) to better understand why they cause symptoms like sneezing and inflammation, which could help find new ways to treat this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $106,711 |
| NIH project number | 7R21AI173476-03 |
| Project ID | NIH-11231567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic rhinosinusitis or allergic fungal rhinosinusitis.
✕Less likely to help
Patients without chronic nasal inflammation or those not affected by allergic responses may not benefit from this research.
What this research studies
This research investigates the role of sensory neurons in the nasal passages and their interaction with specialized cells during allergic reactions, specifically focusing on allergic fungal rhinosinusitis (AFRS). By using a mouse model that mimics the condition, the study aims to uncover how allergens trigger inflammation and sneezing. The researchers will explore the mechanisms by which certain nerve cells become sensitized to allergens and contribute to the symptoms of AFRS, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from chronic rhinosinusitis and related allergic conditions.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding the role of sensory neurons in allergic responses.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Herbert, De'broski R — Tulane University of Louisiana
- Study coordinator: Herbert, De'broski R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.