Understanding how nerve and fibroblast communication affects pain in Ehlers Danlos Syndrome
Official title: The role of Nerve-fibroblast communication in EDS pain
Funded at Rush University Medical Center · NIH-11036741 · Data updated 2026-11-12
This study is looking at how chronic pain works in people with Classic Ehlers Danlos Syndrome (cEDS) by exploring how nerve cells and collagen-producing cells talk to each other, with the goal of finding new ways to manage pain without using opioids.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 23, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $351,223 |
| NIH project number | 1R21AR085242-01 |
| Project ID | NIH-11036741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Classic Ehlers Danlos Syndrome who experience chronic pain.
✕Less likely to help
Patients with other forms of Ehlers Danlos Syndrome or those without chronic pain may not benefit from this research.
What this research studies
This research investigates the mechanisms of chronic pain in patients with Classic Ehlers Danlos Syndrome (cEDS), a condition characterized by skin and joint issues due to genetic defects. The study focuses on the communication between nerve cells and fibroblasts, which are cells that produce collagen and play a role in tissue repair. By examining how these cells interact and contribute to pain sensitivity, the research aims to uncover new non-opioid pain management strategies for cEDS patients. The approach includes both patient assessments and animal models to explore the underlying biological processes involved in pain.
Why it matters
Potential benefit: If successful, this research could lead to innovative non-opioid treatments for chronic pain in EDS patients.
How similar studies have gone: Previous research has shown promising results in understanding pain mechanisms in related conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Malfait, Anne-Marie — Rush University Medical Center
- Study coordinator: Malfait, Anne-Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.