Understanding how nematodes shed their skin
Mechanisms of nematode molting
This study looks at how tiny worms called nematodes shed their skin and how this process might help us understand important things like healing wounds and fighting tumors in humans, which could lead to better treatments for infections caused by these worms that affect many people around the world.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10877170 on NIH RePORTER |
What this research studies
This research investigates the biological processes involved in the molting of nematodes, specifically focusing on the remodeling of the collagenous extracellular matrix that surrounds cells. By studying the nematode C. elegans, the researchers aim to uncover how this process is regulated and how it relates to broader biological functions, including wound healing and tumor invasion in mammals. The study will also explore the hormonal regulation of molting and its connection to diet, providing insights that could inform treatments for parasitic nematode infections affecting millions worldwide.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by parasitic nematode infections or those interested in advancements in wound healing therapies.
Not a fit: Patients with conditions unrelated to nematode infections or extracellular matrix disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating parasitic infections and improving wound healing in humans.
How similar studies have performed: Other research has shown success in understanding similar biological processes in model organisms, suggesting potential for breakthroughs in this area.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Ward, Jordan David — University of California Santa Cruz
- Study coordinator: Ward, Jordan David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.