Understanding how NEIL glycosylases repair damaged DNA
Elucidating Mechanisms of Recognition and Excision of Damaged Bases by NEIL glycosylases
This study is looking at how certain enzymes help fix damaged DNA caused by stress in our bodies, which can lead to health problems like cancer and aging, and it's for anyone interested in understanding how our cells stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10843267 on NIH RePORTER |
What this research studies
This research investigates the role of NEIL glycosylases in repairing damaged DNA caused by oxidative stress, which is linked to various health issues including cancer and aging. The researchers will explore how these enzymes recognize and excise modified DNA bases, focusing on their unique ability to function in different DNA contexts. By examining the mechanisms of these enzymes, the study aims to uncover how they contribute to DNA repair processes that are crucial for maintaining cellular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to oxidative stress, such as certain cancers or age-related disorders.
Not a fit: Patients with no history of oxidative stress-related conditions or those who do not have genetic predispositions to DNA repair deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing DNA repair mechanisms, potentially reducing the risk of cancer and age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: David, Sheila Sue — University of California at Davis
- Study coordinator: David, Sheila Sue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.