Understanding how negative thinking affects mood disorders
Biases in sharp wave-ripple content as a transdiagnostic cognitive process
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-10854735
This study is looking at how certain thought patterns in the brain might connect mood disorders like depression with other conditions such as schizophrenia and PTSD, using mice to help us learn more about these issues and find better treatments for people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10854735 on ClinicalTrials.gov |
What this research studies
This research investigates the shared mechanisms behind various mood disorders and their comorbidities, such as schizophrenia and PTSD. By developing a neural assay to study negatively biased thought processes in mice, the research aims to uncover how these biases contribute to mood disorders. The approach focuses on analyzing sharp wave-ripples in the hippocampus, which are linked to memory and decision-making. This could lead to better understanding and treatment options for mood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing mood disorders, particularly those with comorbid conditions like anxiety or PTSD.
Not a fit: Patients with solely physical health issues or those not experiencing mood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for mood disorders by targeting the cognitive processes that contribute to these conditions.
How similar studies have performed: Other research has shown promise in understanding cognitive biases in mood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN DER MEER, MATTHIJS — DARTMOUTH COLLEGE
- Study coordinator: VAN DER MEER, MATTHIJS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental health disorders, Psychiatric Disease, Psychiatric Disorder