Understanding how negative emotions affect eating behaviors in adults with ARFID

The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions

['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11042226

This study is looking at how negative feelings affect eating habits in adults with avoidant/restrictive food intake disorder (ARFID) by checking their brain activity and hormone levels, and it’s designed for adults who want to understand more about their relationship with food and emotions.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorMASSACHUSETTS GENERAL HOSPITAL (nih funded)
Locations1 site (BOSTON, UNITED STATES)
Trial IDNIH-11042226 on ClinicalTrials.gov

What this research studies

This research investigates the role of negative emotions in avoidant/restrictive food intake disorder (ARFID) by examining the brain's response and hormonal changes in adults. It uses a multi-disciplinary approach, comparing neural circuitry and hormone levels between adults with ARFID and healthy controls. Participants will engage in real-time assessments of their emotions and behaviors related to food, providing insights into how these factors contribute to the disorder. The study aims to uncover the mechanisms that maintain ARFID and inform future treatment strategies.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults diagnosed with avoidant/restrictive food intake disorder.

Not a fit: Patients with eating disorders other than ARFID or those without significant negative affect may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and treatment options for adults suffering from ARFID.

How similar studies have performed: Previous research has shown promising results in understanding the neurobiology of eating disorders, suggesting that this approach could yield valuable insights.

Where this research is happening

BOSTON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.