Understanding how nebulin affects muscle structure and function
Roles of Nebulin in Structure and Function of Striated Muscle
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-10898577
This study is looking at a protein called nebulin and how it affects muscle strength and structure, using mice that have a condition similar to nemaline myopathy, to help find new ways to treat problems caused by changes in this protein.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10898577 on ClinicalTrials.gov |
What this research studies
This research investigates the role of nebulin, a large protein found in skeletal muscle, and its impact on muscle structure and function. By using mouse models that mimic different severities of nemaline myopathy, the research aims to uncover how nebulin regulates muscle fiber length and interacts with other proteins. The study employs advanced techniques such as transcriptomics, proteomics, and super-resolution imaging to gain insights into nebulin's functions at various biological levels. This comprehensive approach is essential for developing potential treatments for conditions related to nebulin mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with nemaline myopathy or related muscle disorders.
Not a fit: Patients with muscle disorders not related to nebulin mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for nemaline myopathy and improve muscle function in affected patients.
How similar studies have performed: Other research has shown promising results in understanding muscle proteins, but the specific focus on nebulin is relatively novel.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRANZIER, HENK L. — UNIVERSITY OF ARIZONA
- Study coordinator: GRANZIER, HENK L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.