Understanding how navigation is affected in Alzheimer's disease
CRCNS: Scale-invariant navigation and its degradation in Alzheimer's disease
This study is looking at how Alzheimer's disease affects the brain's ability to help us find our way around, using both animal models and human behavior to learn more about the problem and create new tools that could improve navigation skills for people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10663375 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms behind navigation and how they are impacted by Alzheimer's disease. It employs a computational framework called SIPI, which helps to understand how neural circuits encode and decode spatial information. By studying both rodent models and human behavior, the research aims to identify how degeneration in the brain affects the ability to navigate. The project will also develop new tools for analyzing navigation processes, which could lead to better understanding and treatment of navigation impairments in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who experience navigation challenges.
Not a fit: Patients with early-stage cognitive impairments unrelated to navigation or those without a diagnosis of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing navigation difficulties in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding navigation mechanisms, but this specific approach using the SIPI framework is relatively novel.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Newman, Ehren L. — Trustees of Indiana University
- Study coordinator: Newman, Ehren L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.