Understanding how naïve T cells contribute to HIV reservoirs
Probing the unique attributes of the naïve reservoir
This study is looking at how certain immune cells called naïve CD4+ T cells might hold onto HIV even when treatment stops, which could help us find better ways to cure HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11063904 on NIH RePORTER |
What this research studies
This research investigates the role of naïve CD4+ T cells in the HIV reservoir, which can lead to the resurgence of the virus when treatment is halted. The study aims to quantify how these naïve cells, which were previously thought to play a minor role, actually contain a significant amount of intact HIV DNA compared to memory T cells. By analyzing the diversity and lifespan of these cells, the research seeks to uncover mechanisms that allow them to sustain the HIV reservoir. This could provide insights into new strategies for achieving an HIV cure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who have never been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative approaches for eradicating HIV from the body.
How similar studies have performed: While the role of memory T cells in HIV reservoirs has been extensively studied, the specific focus on naïve T cells is relatively novel and has not been widely tested.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: O'doherty, Una T — Emory University
- Study coordinator: O'doherty, Una T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.