Understanding how natural selection affects human diseases through genetics
Characterizing genetic signatures of natural selection to understand human diseases
['FUNDING_OTHER'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10885023
This study is looking at how our genes change over time and how those changes can affect diseases, with the goal of helping doctors better understand and treat health issues for people from different backgrounds.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10885023 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic signatures of natural selection and their impact on human diseases. By analyzing large genetic and genomic datasets, the team aims to improve our understanding of complex traits and diseases across different ancestry groups. The approach includes developing models and applying methods to characterize these genetic signatures, which could enhance polygenic risk scores and variant prioritization in clinical settings. This work is crucial for advancing disease prevention and diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse ancestry backgrounds who may be at risk for complex diseases.
Not a fit: Patients with rare diseases that do not have a genetic component or those not represented in the genetic datasets may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of diseases through improved genetic risk assessments.
How similar studies have performed: Other research has shown promise in using genetic signatures to understand diseases, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAZAL, STEVEN — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: GAZAL, STEVEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.