Understanding How Natural Proteins Fight HIV
Structural Virology of Tripartite Motif Proteins
This research aims to understand how certain natural proteins in our bodies, called TRIM proteins, recognize and stop viruses like HIV-1.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11133018 on NIH RePORTER |
What this research studies
Our bodies have special proteins called TRIM proteins that act like a defense system against viruses. This project looks closely at how one of these proteins, TRIM5a, forms a protective cage around the HIV-1 virus to stop it from spreading. Researchers are using advanced techniques to see the detailed structure of this cage and learn exactly how TRIM5a deactivates the virus. They also want to understand how another protein, TRIM34, helps TRIM5a bind to and inactivate HIV-1. This work will help us understand our natural defenses against HIV.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation, but it is highly relevant to individuals living with HIV-1.
Not a fit: Patients without HIV-1 infection would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new ways to develop antiviral medications that boost our body's natural ability to fight HIV-1.
How similar studies have performed: This project builds on the research team's previous success in solving the first structure of the TRIM5a/capsid superlattice and developing new experimental systems.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Pornillos, Owen — Utah State Higher Education System--University of Utah
- Study coordinator: Pornillos, Owen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.