Understanding How Natural Products Are Made
Posttranslational Modifications during Natural Product Biosynthesis
This work explores how living things create special molecules, like those that fight infections, to help us discover new medicines.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-11083648 on NIH RePORTER |
What this research studies
Our bodies and the tiny organisms living within us produce many natural compounds, some of which can act as powerful medicines. This project focuses on a specific group of these compounds called RiPPs, which are found in the human microbiome and are linked to both causing and preventing diseases. We are working to understand the detailed steps involved in making these RiPPs and to develop new tools to harness their potential. A key focus is on lanthipeptides, a type of RiPP known for its ability to fight bacteria, viruses, and fungi.
Who could benefit from this research
Good fit: This foundational laboratory work does not involve direct patient participation, but future patients with infections or other conditions could benefit from new medicines developed from this knowledge.
Not a fit: Patients seeking immediate treatment for existing conditions would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to the discovery and development of new antibiotics, antiviral drugs, and other treatments for various human diseases.
How similar studies have performed: Research in this field has made progress in understanding how some natural products are formed, but much remains unknown about many of these complex processes.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Van Der Donk, Wilfred a. — University of Illinois at Urbana-Champaign
- Study coordinator: Van Der Donk, Wilfred a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.