Understanding how natural killer cells influence HIV antibody responses
Natural killer cell regulation of the germinal center HIV neutralizing antibody response
This study is looking at how certain immune cells called natural killer (NK) cells might help the body make strong antibodies against HIV, and it’s especially for people living with chronic HIV who can help us learn more about this process to improve future vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10738292 on NIH RePORTER |
What this research studies
This research investigates the role of natural killer (NK) cells in the development of broadly neutralizing antibodies (bnAbs) against HIV-1. It aims to understand how NK cell dysregulation affects T follicular helper cells and B cell activity, which are crucial for generating effective antibodies. By exploring these mechanisms, the research seeks to identify new strategies for vaccine development that could enhance the body's ability to produce bnAbs. Patients with chronic HIV infection may provide valuable insights into these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with chronic HIV infection who may have developed or are capable of developing broadly neutralizing antibodies.
Not a fit: Patients who are HIV-negative or those who do not have chronic HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies that effectively induce protective antibodies against HIV.
How similar studies have performed: Previous research has shown that understanding immune cell interactions can lead to advancements in vaccine development, suggesting potential success for this approach.
Where this research is happening
Kansas City, United States
- Children's Mercy Hosp (Kansas City, Mo) — Kansas City, United States (Active)
Researchers
- Principal investigator: Bradley, Todd Christopher — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Bradley, Todd Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.