Understanding how natural killer cells fight viral infections in newborns
The natural killer cell response against mouse cytomegalovirus infection
This study is looking at how special immune cells called natural killer (NK) cells help fight off viral infections, especially in newborns and people with weakened immune systems, to find ways to boost their protection against viruses like cytomegalovirus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10989943 on NIH RePORTER |
What this research studies
This research investigates the role of natural killer (NK) cells in combating viral infections, particularly in newborns and immunocompromised individuals who are vulnerable to viruses like cytomegalovirus. By using a mouse model, the study aims to uncover the cellular and molecular mechanisms that regulate NK cell responses during infection. The researchers will explore how a specific transcription factor, IRF4, influences NK cell activity and identify new gene targets that may enhance the immune response. This work could lead to better strategies for protecting at-risk populations from viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns and individuals with weakened immune systems who are at high risk for viral infections.
Not a fit: Patients with robust immune systems who are not at risk for viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve treatments and preventive measures for viral infections in newborns and immunocompromised patients.
How similar studies have performed: Previous research has shown promising results in understanding NK cell responses, making this approach a continuation of established findings.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Sun, Joseph Chai-Yuen — Sloan-Kettering Inst Can Research
- Study coordinator: Sun, Joseph Chai-Yuen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.