Understanding how natural killer cells develop in the body and their role in cancer.
Official title: Elucidation of Human Natural Killer Cell Development
Funded at Ohio State University · NIH-11083147 · Data updated 2026-11-12
This study is looking at how certain immune cells, called natural killer (NK) cells, grow and work in the body, especially in women with uterine cancer, to find out how cancer might change these cells and help tumors grow, which could lead to better treatments for the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $562,208 |
| NIH project number | 5R01CA208353-08 |
| Project ID | NIH-11083147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with uterine endometrial carcinoma or those interested in understanding immune responses in cancer.
✕Less likely to help
Patients with cancers unrelated to uterine endometrial carcinoma may not benefit directly from this research.
What this research studies
This research investigates the development of natural killer (NK) cells, which are crucial for immune responses, particularly in the context of uterine endometrial carcinoma. The study aims to understand how these cells mature in healthy tissues and how their functions may be altered by cancer. By examining the cellular and molecular processes involved, the research seeks to uncover how tumors might exploit normal NK cell development to enhance their growth and spread. This could lead to new insights into cancer immunotherapy and potential treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by enhancing the body's immune response against tumors.
How similar studies have gone: Previous research has shown promising results in understanding NK cell functions in cancer, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Freud, Aharon G — Ohio State University
- Study coordinator: Freud, Aharon G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.