Understanding how natural compounds fight cancer
Official title: Assigning mode of action to phenotypically discovered anticancer leads.
Funded at Attagene, INC. · NIH-10932976 · Data updated 2026-11-12
This study is exploring how natural products might help treat cancer by looking at how they affect certain proteins in our bodies, which could lead to new and better treatments for cancer patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Attagene, INC. NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | September 21, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,000,000 |
| NIH project number | 5R44CA285062-02 |
| Project ID | NIH-10932976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with various types of cancer who may benefit from novel anticancer therapies.
✕Less likely to help
Patients who are not currently undergoing treatment for cancer or those with conditions unrelated to cancer may not benefit from this research.
What this research studies
This research focuses on identifying how natural products can be used as effective cancer treatments. By using advanced techniques, the team aims to uncover the mechanisms through which these compounds work, which is crucial for developing new drugs. The approach involves analyzing the activity of specific proteins that control gene expression in response to these compounds. This could lead to more efficient drug discovery processes and better-targeted therapies for cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective cancer treatments derived from natural products.
How similar studies have gone: Previous research has shown promise in using natural products for cancer treatment, indicating that this approach could yield significant advancements.
Where this research is happening
-
Attagene, INC.
Research Triangle Park, United States Active
Researchers
- Principal investigator: Makarov, Sergei S — Attagene, INC.
- Study coordinator: Makarov, Sergei S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.