Understanding how NAT2 affects insulin resistance and energy use in the body
Mechanisms of NAT2 Regulation of Insulin Resistance and Mitochondrial Dysfunction
This study is looking at how a gene called NAT2 affects insulin resistance, which is important for people with type 2 diabetes and heart disease, to help us understand how our bodies use energy and manage blood sugar.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10665620 on NIH RePORTER |
What this research studies
This research investigates the role of a specific gene, NAT2, in insulin resistance, which is a key factor in type 2 diabetes and cardiovascular disease. By studying both human genetic data and mouse models, the researchers aim to understand how variations in NAT2 influence glucose metabolism and mitochondrial function. The study employs advanced techniques such as genome-wide association studies and metabolic assessments to explore the relationship between NAT2 and energy utilization in fat and muscle cells. Patients may gain insights into the genetic factors affecting their insulin sensitivity and overall metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with type 2 diabetes or those at risk for insulin resistance.
Not a fit: Patients without insulin resistance or type 2 diabetes may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving insulin sensitivity and reducing the risk of type 2 diabetes and cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on insulin resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Knowles, Joshua Wiley — Stanford University
- Study coordinator: Knowles, Joshua Wiley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.