Understanding how nairovirus affects the body's immune response
Origin of the innate immunity suppression caused by nairovirus' protease activity
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA RIVERSIDE · NIH-10897316
This study is looking at how the Crimean-Congo hemorrhagic fever virus tricks our immune system into not fighting it off, and it's for anyone interested in finding new ways to treat infections caused by this virus and similar ones.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA RIVERSIDE (nih funded) |
| Locations | 1 site (RIVERSIDE, UNITED STATES) |
| Trial ID | NIH-10897316 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the nairovirus, specifically the Crimean-Congo hemorrhagic fever virus (CCHFV), suppresses the innate immune response in humans. The study focuses on the viral protease activity and its role in modifying host proteins that are crucial for immune function. By examining these interactions, researchers aim to uncover potential therapeutic targets that could lead to effective treatments for infections caused by CCHFV and related viruses. The findings could provide insights into the broader implications of nairovirus infections and their impact on public health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to or infected with the Crimean-Congo hemorrhagic fever virus or other related nairoviruses.
Not a fit: Patients who are not at risk of exposure to nairoviruses or those with unrelated viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for nairovirus infections, potentially reducing mortality rates and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding viral protease functions in other viruses, indicating potential for success in this area of investigation.
Where this research is happening
RIVERSIDE, UNITED STATES
- UNIVERSITY OF CALIFORNIA RIVERSIDE — RIVERSIDE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEGAN, SCOTT DUSAN — UNIVERSITY OF CALIFORNIA RIVERSIDE
- Study coordinator: PEGAN, SCOTT DUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Diseases