Understanding how NAIP receptors detect bacteria and trigger inflammation
Elucidating the Structural Mechanisms of NAIP Receptors in Bacterial Detection and Inflammasome Activation
This study is looking at how certain receptors in our immune system help our bodies fight off bacterial infections by triggering inflammation, and it aims to understand how these receptors work so we can better understand our body's defenses against infections and related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-11190035 on NIH RePORTER |
What this research studies
This research investigates the role of NAIP receptors in the immune response to bacterial infections. It focuses on how these receptors activate inflammasomes, which are crucial for initiating inflammation and cell death in response to pathogens. By examining the structural mechanisms of NAIP receptors, the research aims to uncover how they recognize specific bacterial components and how they remain inactive in resting cells. This could lead to insights into the body's defense mechanisms against infections and inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoinflammatory diseases or those affected by bacterial infections.
Not a fit: Patients with non-infectious inflammatory conditions or those not affected by bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to new treatments for autoinflammatory diseases and infections.
How similar studies have performed: Previous research has shown success in understanding inflammasome activation, but the specific mechanisms of NAIP receptors in humans remain largely untested.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Zhang, Liman — Van Andel Research Institute
- Study coordinator: Zhang, Liman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.