Understanding how NAD+ levels affect aging and cellular health
Dissecting metabolic control by cytosolic-mitochondrial NAD compartmentalization
This study is looking at how a substance called NAD+ works in our cells, especially in the parts that help produce energy, to see if it can help us understand and improve health as we age and tackle age-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11061316 on NIH RePORTER |
What this research studies
This research investigates the role of nicotinamide adenine dinucleotide (NAD+) in cellular processes related to aging and various age-related diseases. It aims to uncover how NAD+ is compartmentalized within cells, particularly in mitochondria, and how this affects metabolism and cellular signaling. By studying a specific mitochondrial transporter, SLC25A51, the research seeks to understand its impact on NAD+ levels and overall cellular health. Patients may benefit from insights that could lead to new treatments for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals experiencing age-related health issues.
Not a fit: Patients with acute, non-age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance cellular health and combat age-related diseases.
How similar studies have performed: Previous research has shown that increasing NAD+ levels can improve healthspan, indicating potential success for this approach.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Kory, Nora — Harvard School of Public Health
- Study coordinator: Kory, Nora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.