Understanding how NAD+ affects muscle development and health in zebrafish with a specific muscle disorder
Mechanisms of NAD+ action during muscle development and homeostasis in a zebrafish dystroglycanopathy model
This study is looking at how a molecule called NAD+ helps muscles grow and stay healthy, using zebrafish that have a condition similar to muscular dystrophy, to find out how muscle cells stick to their surroundings and what that means for muscle strength and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maine Orono NIH-funded |
| Lab location | 1 site (Orono, United States) |
| Project ID | NIH-10667315 on NIH RePORTER |
What this research studies
This research investigates the role of NAD+ in muscle development and maintenance, particularly in zebrafish models that mimic a type of congenital muscular dystrophy. The study focuses on how muscle cells adhere to their surrounding extracellular matrix, which is crucial for muscle function and resilience. By examining the interactions between specific proteins involved in this adhesion process, the researchers aim to uncover the cellular mechanisms that NAD+ influences to improve muscle health. This could lead to insights into potential therapeutic strategies for muscle disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with congenital muscular dystrophies or related muscle disorders.
Not a fit: Patients with muscle disorders not related to adhesion issues or those without genetic mutations affecting muscle-ECM interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for congenital muscular dystrophies, improving muscle function and quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding muscle-ECM interactions and the role of NAD+ in muscle health, indicating that this approach has potential for success.
Where this research is happening
Orono, United States
- University of Maine Orono — Orono, United States (Active)
Researchers
- Principal investigator: Henry, Clarissa a — University of Maine Orono
- Study coordinator: Henry, Clarissa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.