Understanding how NAD+ affects kidney development and health
Official title: Elucidating the Role of NAD+ and PARylation in Nephron Endowment
Funded at Ut Southwestern Medical Center · NIH-11054819 · Data updated 2026-11-12
This study is looking at how a mother's nutrition and health during pregnancy can affect a substance called NAD+, which is important for the development of healthy kidneys in babies, and it hopes to find out how this connection might help prevent kidney problems later in life.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | May 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $168,886 |
| NIH project number | 1K08DK138291-01A1 |
| Project ID | NIH-11054819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women, particularly those with conditions that may affect NAD+ levels, such as malnutrition or diabetes.
✕Less likely to help
Patients who are not pregnant or those without risk factors for chronic kidney disease may not benefit from this research.
What this research studies
This research investigates the role of nicotinamide adenine dinucleotide (NAD+) in the development of nephrons, the functional units of the kidneys. It focuses on how maternal nutrition and health conditions can influence the availability of NAD+ during pregnancy, potentially affecting the kidney health of infants. The study will utilize innovative biosensors to explore how NAD+ impacts the differentiation of nephron progenitor cells, which are crucial for kidney formation. By examining these relationships, the research aims to uncover mechanisms that could lead to chronic kidney disease later in life.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing chronic kidney disease by improving maternal health and nutrition during pregnancy.
How similar studies have gone: Previous research has shown promising results regarding the role of NAD+ in cellular differentiation and health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Clark, Amanda J — Ut Southwestern Medical Center
- Study coordinator: Clark, Amanda J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.