Understanding how N-terminal methylation affects aging and cancer
Expanding the biological roles of N-terminal methylation
This study, led by Dr. Schaner Tooley, is looking at how a special process that changes proteins might play a role in cancer and aging, with the goal of finding new ways to understand and treat age-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11005725 on NIH RePORTER |
What this research studies
This research investigates the biological roles of N-terminal methylation, a process that modifies proteins and influences their function. The team, led by Dr. Schaner Tooley, aims to uncover how this modification affects protein interactions and contributes to conditions like cancer and aging. By studying specific enzymes and their substrates, they hope to reveal new insights into how these processes regulate cell behavior and fate. This could lead to a better understanding of age-related diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related diseases or cancers, particularly those with a family history of such conditions.
Not a fit: Patients with non-age-related conditions or those not affected by cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related diseases and cancers by targeting the mechanisms of N-terminal methylation.
How similar studies have performed: Previous research has shown promising results in understanding post-translational modifications and their roles in diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Schaner-Tooley, Christine E — State University of New York at Buffalo
- Study coordinator: Schaner-Tooley, Christine E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.