Understanding how myosin II affects memory related to methamphetamine and opioids
Myosin II regulation of actin dynamics and the selective vulnerability of methamphetamine- and opioid-associated memory
This study is looking at how certain proteins in the brain affect memories related to methamphetamine and opioid use, with the goal of finding new ways to help people avoid relapse into substance use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10745955 on NIH RePORTER |
What this research studies
This research investigates the role of nonmuscle myosin II in regulating actin dynamics, which are crucial for memory formation and stability, particularly in the context of methamphetamine and opioid use. The study aims to understand how memories associated with these substances can lead to relapse and how disrupting the actin cytoskeleton in the amygdala can selectively target these memories. By exploring the mechanisms behind memory retrieval and the potential for pharmacological intervention, the research seeks to develop new strategies to prevent relapse in individuals with substance use disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of methamphetamine or opioid use who are at risk of relapse.
Not a fit: Patients who have not used methamphetamine or opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent relapse in individuals recovering from methamphetamine and opioid addiction.
How similar studies have performed: Previous research has shown promising results in targeting actin dynamics for memory disruption, indicating potential for success in this novel approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Miller, Courtney a — University of Florida
- Study coordinator: Miller, Courtney a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.