Understanding how Myosin 5b affects microvilli during inflammation
Official title: Elucidating the role of Myosin 5b in microvilli assembly and in the setting of inflammation
Funded at Medical University of South Carolina · NIH-11065446 · Data updated 2026-11-12
This study is looking at how a protein called Myosin 5b helps tiny structures in your intestines, called microvilli, work properly, especially when inflammation from conditions like Crohn's disease gets in the way, with the hope of finding better ways to treat inflammatory bowel disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $44,698 |
| NIH project number | 5F31DK139736-02 |
| Project ID | NIH-11065446 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease or ulcerative colitis, particularly those experiencing gastrointestinal inflammation.
✕Less likely to help
Patients without inflammatory bowel disease or those with other unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates the role of Myosin 5b in the assembly of microvilli, which are tiny projections on intestinal cells that play a crucial role in nutrient absorption. The study focuses on how inflammation, particularly in conditions like Crohn's disease, disrupts the normal function and structure of these microvilli. By examining the interactions between Myosin 5b and the proteins that connect microvilli, researchers aim to uncover the mechanisms behind gastrointestinal inflammation and its impact on health. This could lead to new insights into the treatment of inflammatory bowel disease (IBD).
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory bowel disease, potentially enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the role of microvilli in gastrointestinal health, indicating that this approach has potential for success.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Dooley, Sarah a — Medical University of South Carolina
- Study coordinator: Dooley, Sarah a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.