Understanding how myeloid cells produce creatine in glioblastoma
Official title: The hypoxic niche in glioblastoma is maintained by myeloid produced creatine
Funded at Northwestern University at Chicago · NIH-11081627 · Data updated 2026-11-12
This study is looking at how certain immune cells in glioblastoma tumors help produce a substance called creatine in low-oxygen areas, and how this affects the tumor's growth and ability to resist treatment, with the hope of finding better ways to treat glioblastoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $331,915 |
| NIH project number | 5R01CA279686-03 |
| Project ID | NIH-11081627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma, particularly those experiencing treatment resistance.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates the role of myeloid cells in producing creatine within glioblastoma tumors, particularly in areas of low oxygen known as hypoxic niches. By analyzing both human and mouse models, the study aims to understand how this creatine production affects tumor growth and resistance to therapies. The researchers will explore the relationship between creatine transport and glioma stem cell characteristics, which are crucial for the tumor's survival and progression. This work could lead to new insights into how to effectively treat glioblastoma by targeting these metabolic interactions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve outcomes for patients with glioblastoma.
How similar studies have gone: Previous research has shown promising results in understanding the metabolic interactions in glioblastoma, but this specific approach focusing on myeloid-derived creatine is relatively novel.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Miska, Jason — Northwestern University at Chicago
- Study coordinator: Miska, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.