Understanding how myeloid cells can hide HIV-1 from treatment
Official title: Irreversible Proviral Silencing in Myeloid Cells
Funded at University of Miami School of Medicine · NIH-10897903 · Data updated 2026-11-12
This study is looking at how certain immune cells can keep the HIV-1 virus hidden in people who are on treatment, and it aims to find new ways to help get rid of the virus for good.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 2, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $230,250 |
| NIH project number | 5R21AI172772-02 |
| Project ID | NIH-10897903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are currently on effective ART and have experienced viral rebound.
✕Less likely to help
Patients who are not infected with HIV-1 or those who are not on ART may not benefit from this research.
What this research studies
This research investigates how certain immune cells, specifically myeloid cells, can harbor the HIV-1 virus even in patients receiving effective antiretroviral therapy (ART). The team aims to create a model to study the latency of the virus in these cells, focusing on how specific cellular mechanisms can lead to the virus remaining undetected and persistent. By examining the role of NF-kB inhibition, the researchers hope to uncover new insights into the epigenetic changes that allow the virus to evade treatment. This could lead to innovative strategies for eliminating HIV-1 from the body.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV-1 from patients, potentially curing the infection.
How similar studies have gone: Previous research has shown that targeting viral reservoirs in immune cells can lead to significant advancements in HIV treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Stevenson, Mario — University of Miami School of Medicine
- Study coordinator: Stevenson, Mario
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.