Understanding how myelin loss affects brain function and movement
The role of myelination in cortical circuit function and motor behavior
This study looks at how the loss of myelin affects brain function and movement in people with Multiple Sclerosis, using special imaging to see changes in the brain that might help us find better ways to improve movement and thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10903363 on NIH RePORTER |
What this research studies
This research investigates the impact of myelin loss on brain circuits and motor behavior, particularly in patients with Multiple Sclerosis (MS). It utilizes advanced imaging techniques to observe changes in brain activity and how these relate to physical and cognitive impairments. By studying the relationship between demyelination and neuronal activity, the research aims to uncover mechanisms that contribute to motor dysfunction in MS patients. The findings could lead to new therapeutic strategies to improve motor function and cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Multiple Sclerosis who experience motor dysfunction or cognitive decline.
Not a fit: Patients with other neurological disorders unrelated to demyelination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance motor function and cognitive abilities in patients with Multiple Sclerosis.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between myelin loss and brain function, indicating that this approach has potential for significant advancements.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Welle, Cristin G — University of Colorado Denver
- Study coordinator: Welle, Cristin G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.