Understanding how myelin is targeted in the central nervous system
Mechanisms of CNS myelin targeting
This study is looking at how certain genes help myelin, which protects nerve fibers in the brain and spinal cord, get to where it needs to go, and it’s for anyone interested in understanding why some nerves are covered in myelin while others aren’t, which could help with conditions related to myelin.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11134443 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which certain genes influence the targeting of myelin to axons in the central nervous system (CNS). It focuses on specific proteins, such as junction adhesion molecules and transmembrane proteins, that may regulate myelination processes. By studying these proteins in model organisms like zebrafish and mice, the research aims to uncover why some axons are myelinated while others are not. The findings could lead to a better understanding of myelin-related disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that involve myelin damage or dysfunction.
Not a fit: Patients with conditions unrelated to myelin or CNS development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to myelin dysfunction, such as multiple sclerosis.
How similar studies have performed: Previous research has shown promising results in understanding myelination processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Kucenas, Sarah C — University of Virginia
- Study coordinator: Kucenas, Sarah C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.