Understanding how myelin is formed and regulated in the brain
Official title: Molecular and genetic regulation of myelin capacity in the CNS
Funded at Oregon Health & Science University · NIH-11127284 · Data updated 2026-11-12
This study is looking at how certain proteins help build and maintain the protective covering around nerves in the brain and spinal cord, which is important for healthy nerve function, and it aims to find ways to support this process in conditions like multiple sclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 19, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $576,142 |
| NIH project number | 1R01NS138188-01A1 |
| Project ID | NIH-11127284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with conditions affecting myelin, such as multiple sclerosis or leukodystrophies.
✕Less likely to help
Patients with conditions unrelated to myelin disruption or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the molecular and genetic factors that control the development of myelin in the central nervous system, which is crucial for proper nerve function. By using animal models, including zebrafish and mice, the study aims to uncover how specific proteins influence the formation and maintenance of myelin. The research focuses on two key regulators, Fbxw7 and Myrf, to understand their roles in myelination and potential strategies for promoting remyelination in diseases like multiple sclerosis.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance myelin repair in patients with demyelinating diseases.
How similar studies have gone: Previous research has shown promising results in understanding myelin regulation, but this specific approach is novel and aims to fill critical gaps in current knowledge.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Monk, Kelly R — Oregon Health & Science University
- Study coordinator: Monk, Kelly R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.