Understanding how myelin changes affect behavior in health and Multiple Sclerosis.
Precision of Myelin Plasticity in Health and Disease
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-10982500
This study looks at how brain activity affects the protective covering of nerve cells, called myelin, and how these changes can influence movement skills, with the goal of finding new ways to help people with conditions like Multiple Sclerosis improve their motor abilities.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10982500 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between neuronal activity and myelin changes in the brain, particularly focusing on how these changes impact motor behavior. By using advanced imaging techniques, the study aims to visualize myelin and its cells in the brain, providing insights into how behavior influences myelination and repair processes. The research will evaluate how specific neuronal circuits regulate myelin during learning and how these changes affect motor skills. This could lead to new behavioral interventions that enhance remyelination in conditions like Multiple Sclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Multiple Sclerosis who are interested in understanding and potentially improving their motor skills.
Not a fit: Patients with conditions unrelated to myelin or central nervous system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve motor function and quality of life for patients with Multiple Sclerosis.
How similar studies have performed: Previous research has shown promise in understanding myelin dynamics and its impact on behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUGHES, ETHAN GARRETT — UNIVERSITY OF COLORADO DENVER
- Study coordinator: HUGHES, ETHAN GARRETT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.