Understanding how myelin affects balance and movement control
How myelin regulates vestibular circuit function and balance behaviors
['FUNDING_CAREER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11045780
This study is looking at how losing myelin affects balance in people with multiple sclerosis, using zebrafish to see how this loss changes the way certain brain cells work, with the hope of finding ways to improve balance by restoring myelin.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11045780 on ClinicalTrials.gov |
What this research studies
This research investigates the role of myelin in the functioning of neural circuits that control balance, particularly in conditions like multiple sclerosis where myelin is lost. Using zebrafish larvae as a model, the study will observe how myelin loss impacts balance behaviors and the responses of specific neurons in the vestibulospinal circuit. The research aims to uncover the mechanisms behind balance issues caused by demyelination and explore potential ways to restore myelin and improve balance. Through targeted experiments, the project will assess the effects of myelin loss and the potential for recovery through remyelination.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with demyelinating conditions, such as multiple sclerosis, who experience balance issues.
Not a fit: Patients without demyelinating diseases or those who do not experience balance problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for balance disorders associated with demyelinating diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of myelin in neural function, but this specific approach using zebrafish is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AUER, FRANZISKA — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: AUER, FRANZISKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.