Understanding how Myct1 affects blood vessel growth and immune response in cancer
Myct1 control of the angioimmune interface
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11093939
This study is looking at a protein called Myct1 to see how it helps control blood vessel growth and immune responses in tumors, which could lead to better cancer treatments that limit blood vessel formation while boosting the body's immune attack on cancer cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11093939 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Myct1, a protein found in endothelial cells, in regulating blood vessel formation and immune responses in tumors. By studying genetically modified mice and human cancer samples, the researchers aim to understand how Myct1 influences both angiogenesis and the activity of immune cells, particularly CD8+ T lymphocytes. The approach includes using knockout models and treatments with antibodies to explore the potential for improved cancer therapies that reduce blood vessel growth while enhancing immune response against tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who may benefit from therapies that target angiogenesis and enhance immune cell activity.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not involve angiogenesis may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer treatments that effectively control tumor growth by targeting blood vessel formation and boosting the immune response.
How similar studies have performed: Previous research has shown promising results in targeting angiogenesis and enhancing immune responses in cancer, suggesting that this approach could be effective.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOI, KYUNGHEE — WASHINGTON UNIVERSITY
- Study coordinator: CHOI, KYUNGHEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.