Understanding how Mycoplasma genitalium changes during long-term infections in macaques
Antigenic variation of Mycoplasma genitalium during persistent genital tract infection of pig-tailed macaques
This study is looking at how a sexually transmitted bacterium called Mycoplasma genitalium behaves during long-lasting infections in pig-tailed macaques, which helps us understand how it hides from the immune system, so we can find better ways to treat infections in people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10516741 on NIH RePORTER |
What this research studies
This research investigates the behavior of Mycoplasma genitalium, a sexually transmitted bacterium, during persistent infections in pig-tailed macaques. By using this animal model, the study aims to explore how the bacterium alters its surface proteins to evade the immune system, which is crucial for developing better treatments. The research will involve monitoring the infection and immune response over time, providing insights that are difficult to obtain from human patients due to the need for immediate treatment. The findings could lead to improved diagnostic and therapeutic strategies for managing Mycoplasma genitalium infections in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals at high risk for Mycoplasma genitalium infections, particularly those experiencing related reproductive health issues.
Not a fit: Patients who are not at risk for Mycoplasma genitalium infections or those who have already been effectively treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Mycoplasma genitalium infections, potentially reducing complications such as infertility and spontaneous abortion.
How similar studies have performed: Other research has shown success in using animal models to study sexually transmitted infections, indicating that this approach has the potential to yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Wood, Gwendolyn — University of Washington
- Study coordinator: Wood, Gwendolyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.