Understanding how Mycobacterium tuberculosis responds to its environment and affects treatment outcomes
Mycobacterium tuberculosis environmental signal integration: single cell in vivo understanding of its influence on infection heterogeneity and treatment efficacy
This study is looking at how the bacteria that cause tuberculosis change in different environments inside the body, which can help us find better ways to treat the infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10684689 on NIH RePORTER |
What this research studies
This research investigates how Mycobacterium tuberculosis (Mtb) adapts to different ionic environments in the body, which can influence the effectiveness of treatments. By using advanced fluorescent reporter strains, the study aims to uncover the mechanisms behind Mtb's response to various environmental signals, such as pH and chloride levels. The research will involve detailed transcriptional studies and screening for new regulatory factors that affect Mtb's behavior during infection. Ultimately, this work seeks to improve our understanding of infection heterogeneity and treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis who may benefit from improved treatment strategies.
Not a fit: Patients with non-tuberculosis infections or those who do not have a confirmed diagnosis of tuberculosis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for tuberculosis by tailoring therapies based on the specific environmental conditions affecting the bacteria.
How similar studies have performed: Previous research has shown that understanding bacterial responses to environmental cues can lead to significant advancements in treatment strategies, suggesting potential success for this approach.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Tan, Shumin — Tufts University Boston
- Study coordinator: Tan, Shumin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.