Understanding how Mycobacterium tuberculosis modifies its cell surface to survive in the host
Tailoring modifications of polysaccharides in Mycobacterium tuberculosis
['FUNDING_R01'] · COLORADO STATE UNIVERSITY · NIH-10909278
This study looks at how changes in the outer layer of the tuberculosis bacteria affect how it interacts with the body and avoids the immune system, helping researchers understand more about how the infection works.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-10909278 on ClinicalTrials.gov |
What this research studies
This research investigates the modifications of cell envelope glycans in Mycobacterium tuberculosis, focusing on how these changes affect the bacteria's interaction with its environment and its ability to evade the immune system. By studying the biosynthetic pathways responsible for these modifications, researchers aim to uncover the biological significance of these changes in the context of tuberculosis infection. The project employs a multidisciplinary approach, combining genetics, immunology, and carbohydrate chemistry to explore the role of specific sugar modifications in the bacteria's pathogenicity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with Mycobacterium tuberculosis or those at high risk of tuberculosis infection.
Not a fit: Patients who are not infected with Mycobacterium tuberculosis or who do not have a history of tuberculosis exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing tuberculosis by targeting the mechanisms that allow the bacteria to survive and evade the immune response.
How similar studies have performed: Previous research has shown success in understanding bacterial cell surface modifications, suggesting that this approach could yield valuable insights into tuberculosis.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACKSON, MARY — COLORADO STATE UNIVERSITY
- Study coordinator: JACKSON, MARY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.