Understanding how Mycobacterium tuberculosis interacts with the human immune system
Network Dissection of Host-Pathogen Interactions in Mycobacterium tuberculosis Infection
['FUNDING_OTHER'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10891689
This study is looking at how the tuberculosis germ interacts with our immune system to see why some people stay healthy while others get sick, with the hope of finding new ways to help protect people from getting active tuberculosis.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10891689 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between the Mycobacterium tuberculosis (Mtb) pathogen and the human immune system. By examining how Mtb manipulates host cell signaling and gene regulation, the study aims to identify key genes that influence whether an infection remains asymptomatic or progresses to active tuberculosis. The research utilizes primary human monocyte-derived macrophages to analyze the transcriptional responses of both the host and the pathogen, with the goal of discovering new therapeutic strategies that can enhance host protection while targeting the pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk of tuberculosis infection or those who have been diagnosed with latent tuberculosis.
Not a fit: Patients with active tuberculosis who are already receiving standard treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve the management and outcomes of tuberculosis infections.
How similar studies have performed: Previous research has shown promise in understanding host-pathogen interactions, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, SHUYI — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: MA, SHUYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.