Understanding how Mycobacterium tuberculosis interacts with immune cells
Investigating the role of liquid-liquid phase separation in the interaction between Mycobacterium tuberculosis and macrophages
This study looks at how the tuberculosis bacteria interact with immune cells in our body, focusing on a special process that helps the bacteria avoid being attacked, with the goal of finding new ways to help our immune system fight off the infection better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10894165 on NIH RePORTER |
What this research studies
This research investigates the interactions between Mycobacterium tuberculosis (Mtb) and macrophages, which are crucial immune cells in the body. It focuses on a phenomenon called liquid-liquid phase separation, where proteins form droplets that can influence how cells respond to infections. By studying these interactions, the research aims to uncover how Mtb evades the immune response and how the body can better fight this infection. This could lead to new insights into the mechanisms of tuberculosis and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are infected with Mycobacterium tuberculosis or are at high risk of tuberculosis infection.
Not a fit: Patients who do not have a history of tuberculosis infection or are not at risk for it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating tuberculosis and enhancing the immune response against this pathogen.
How similar studies have performed: While the specific approach of studying phase separation in the context of Mtb is relatively novel, similar research has shown promise in understanding other infectious diseases and immune responses.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Bell, Samantha Lynn — Rutgers Biomedical and Health Sciences
- Study coordinator: Bell, Samantha Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.