Understanding how mycobacterial proteins affect tuberculosis and immune responses
Role of mycobacterial dynamin-like proteins in the biogenesis of membrane vesicles, and host-pathogen interactions
This study is looking at how certain proteins made by the bacteria that cause tuberculosis help them hide from our immune system, with the hope of finding new ways to fight the disease, especially when antibiotics aren't working as well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10883667 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins produced by the tuberculosis-causing bacteria, Mycobacterium tuberculosis, in their ability to evade the human immune system. By studying how these proteins contribute to the formation of membrane vesicles, the research aims to uncover new ways that the bacteria communicate and manipulate immune responses. The approach includes examining the molecular mechanisms of vesicle production and their impact on immune cells, which could lead to innovative strategies for combating tuberculosis, especially in the face of antibiotic resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, especially those with antibiotic-resistant forms of the disease.
Not a fit: Patients who do not have tuberculosis or are not at risk for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating tuberculosis, particularly against antibiotic-resistant strains.
How similar studies have performed: Previous research has shown promise in targeting bacterial factors for tuberculosis treatment, indicating that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Rodriguez, Gloria Marcela — Rutgers Biomedical and Health Sciences
- Study coordinator: Rodriguez, Gloria Marcela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.