Understanding how mycobacteria recognize each other
Official title: Characterization of a novel kin recognition system in mycobacteria
Funded at Wadsworth Center · NIH-11018604 · Data updated 2026-11-12
This study looks at how certain bacteria, like those that can cause infections, share genes with each other in a special way, and it focuses on a gene that helps them recognize their own kind to avoid mixing with similar bacteria; understanding this could lead to better treatments for infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wadsworth Center NIH-funded |
| Lab location | 1 site (Menands, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $442,353 |
| NIH project number | 5R01AI181948-02 |
| Project ID | NIH-11018604 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by mycobacteria, such as those with tuberculosis or non-tuberculous mycobacterial diseases.
✕Less likely to help
Patients with infections caused by other types of bacteria or those without bacterial infections may not benefit from this research.
What this research studies
This research investigates a unique process in mycobacteria called Distributive Conjugal Transfer (DCT), which allows these bacteria to exchange genetic material in a way similar to sexual reproduction. The study focuses on a specific gene, midA, that helps mycobacteria identify themselves and prevent genetic exchange with similar cells. By exploring how this kin recognition works, the researchers aim to uncover the mechanisms behind bacterial evolution and gene transfer. Patients may benefit from insights gained about mycobacterial behavior, which could inform treatments for infections caused by these bacteria.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating mycobacterial infections by understanding their genetic exchange mechanisms.
How similar studies have gone: While the concept of kin recognition in bacteria is relatively novel, similar studies in other bacterial species have shown promising results in understanding genetic exchange.
Where this research is happening
-
Wadsworth Center
Menands, United States Active
Researchers
- Principal investigator: Gray, Todd — Wadsworth Center
- Study coordinator: Gray, Todd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.