Understanding how mycobacteria control their cell wall and resist antibiotics
Control of cell wall synthesis and antibiotic tolerance in mycobacteria
['FUNDING_R01'] · UNIVERSITY OF TEXAS ARLINGTON · NIH-10844678
This study is looking at how the tuberculosis bacteria manage their cell wall to survive and resist antibiotics, with the hope that understanding this process will help create better treatments for patients with tuberculosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS ARLINGTON (nih funded) |
| Locations | 1 site (ARLINGTON, UNITED STATES) |
| Trial ID | NIH-10844678 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which Mycobacterium tuberculosis regulates its cell wall metabolism, which is crucial for its survival and ability to resist antibiotics. The study focuses on how specific proteins, influenced by environmental signals, control the cell wall's structure and function. By examining the role of a phosphatase enzyme and other regulators, the research aims to uncover new insights that could lead to the development of more effective treatments for tuberculosis. Patients may benefit from this work as it seeks to improve our understanding of antibiotic tolerance in this dangerous pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those who have shown antibiotic resistance.
Not a fit: Patients with non-tuberculosis infections or those who do not have antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective antibiotics for treating tuberculosis.
How similar studies have performed: Previous research has shown promise in understanding antibiotic resistance mechanisms in bacteria, suggesting that this approach could yield valuable insights.
Where this research is happening
ARLINGTON, UNITED STATES
- UNIVERSITY OF TEXAS ARLINGTON — ARLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOUTTE, CARA CHENEY — UNIVERSITY OF TEXAS ARLINGTON
- Study coordinator: BOUTTE, CARA CHENEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.