Understanding how mutations in the PPP2R1A gene affect cancer development
Official title: Deciphering the Functional Role of PPP2R1A Mutations in Cancer
Funded at University of Michigan at Ann Arbor · NIH-11065716 · Data updated 2026-11-12
This study is looking at changes in a gene called PPP2R1A that can cause certain types of gynecological cancers, and it's trying to find new treatments that could help patients by fixing those gene changes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,545 |
| NIH project number | 1F31CA298229-01 |
| Project ID | NIH-11065716 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with high-grade gynecological cancers, particularly those with identified PPP2R1A mutations.
✕Less likely to help
Patients with cancers unrelated to PPP2R1A mutations or those with early-stage cancers may not benefit from this research.
What this research studies
This research investigates the role of mutations in the PPP2R1A gene, which is often altered in high-grade gynecological cancers. By utilizing advanced techniques like next-generation sequencing, the study aims to understand how these mutations disrupt normal cellular functions and contribute to tumor growth. The researchers are exploring small molecules that can restore the function of the mutated gene, potentially leading to new treatment options for affected patients. This work could provide insights into personalized cancer therapies based on genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that specifically target cancers associated with PPP2R1A mutations.
How similar studies have gone: Previous research has shown promising results in targeting similar genetic mutations in cancer, indicating potential for success in this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Harold, Alexis Catherine — University of Michigan at Ann Arbor
- Study coordinator: Harold, Alexis Catherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.