Understanding how mutations in the CLPB gene affect blood cell development
Official title: Mechanistic links between mutations in the CLPB gene and congenital neutropenia
Funded at Kansas State University · NIH-10630259 · Data updated 2026-11-12
This study is looking at how changes in the CLPB gene can cause congenital neutropenia, a condition that makes it hard for your body to make white blood cells, which are important for fighting infections, and the researchers hope to find ways to help people with this condition feel better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $191,406 |
| NIH project number | 5R21AI166525-02 |
| Project ID | NIH-10630259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with congenital neutropenia, particularly those with known mutations in the CLPB gene.
✕Less likely to help
Patients without congenital neutropenia or those whose condition is not linked to mutations in the CLPB gene may not benefit from this research.
What this research studies
This research investigates the role of the CLPB gene in congenital neutropenia, a serious condition that affects the body's ability to produce white blood cells. The researchers will explore how mutations in this gene disrupt normal cell function and lead to severe health issues, including life-threatening infections. By using cell line models, they aim to understand the molecular mechanisms involved in neutrophil differentiation and how these processes are altered by genetic mutations. This could provide insights into potential therapeutic approaches for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with congenital neutropenia.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding genetic causes of blood disorders.
Where this research is happening
-
Kansas State University
Manhattan, United States Active
Researchers
- Principal investigator: Zolkiewska, Anna — Kansas State University
- Study coordinator: Zolkiewska, Anna
Related research
Other NIH-funded projects on the same topics.
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Severe Chronic Neutropenia Registry for Patients
A patient-facing registry that tracks severe chronic low neutrophil counts to improve understanding and care for people with this condition.
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Severe Chronic Neutropenia Registry to Improve Care
A patient-focused registry gathers information from adults with severe chronic neutropenia to better understand infections, treatments, and outcomes over time.
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Severe Chronic Neutropenia Registry: Finding Better Ways to Prevent Infections
A patient-focused registry at a leading hospital helps people with severe chronic neutropenia learn how the condition progresses and how treatments work over time.
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Stimulant that grows donor stem cells in the body to speed neutropenia recovery after chemotherapy and stem cell transplant
A drug given during or right before stem cell transplant helps donor stem cells multiply quickly inside the patient to shorten neutropenia after treatment.
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Stimulant to grow stem cells in the body to speed recovery after chemotherapy and stem cell transplant
A new drug given briefly before transplant aims to help patients recover their blood and immune system faster after chemotherapy or stem cell transplant.
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PointCheck: a home-based, non-invasive neutropenia monitor for chemotherapy patients
A portable, non-invasive device helps cancer patients on chemotherapy monitor neutropenia from home so doctors can prevent serious infections.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.