Understanding how mutations in the CHCHD10 gene affect Alzheimer's and related dementias.
Pathological signatures of CHCHD10 dysfunction in ADRDs
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10863868
This study is looking at how changes in a specific gene called CHCHD10 might affect people with dementia, like Alzheimer's and Frontotemporal Dementia, by using mice and human samples to understand how these changes can harm brain cells and lead to the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10863868 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the CHCHD10 gene, which is linked to various forms of dementia, including Alzheimer's disease and Frontotemporal Dementia. By using mouse models and human tissue samples, the study aims to uncover the pathological changes caused by mutations in this gene. The researchers will employ a range of techniques, including molecular and biochemical analyses, to explore how these mutations lead to mitochondrial dysfunction and contribute to the progression of dementia. This work could provide insights into the underlying mechanisms of these diseases and identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, Frontotemporal Dementia, or those with known CHCHD10 mutations.
Not a fit: Patients with dementia not associated with CHCHD10 mutations or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors contributing to dementia, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANG, DAVID E — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: KANG, DAVID E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia, Alzheimer's disease and related disorders